1) Remove the cap and place the can on a table or flat surface holding it by the collar. 2) Firmly hold the collar between your thumb and index finger, twist the cone in counter clockwise direction with your other hand and firmly push down the cone for 3 seconds without touching the metal tip. You will now hear the activation sound (hiss). 3) Be sure the cone twists back to zero automatically to lock the system before applying the product. Wait for 2 seconds while the metal tip freezes. 4) Precisely apply the frozen metal tip on the wart (hand) for 20 seconds or on the plantar wart (foot) for 40 seconds to freeze it.